Altered Pharmacokinetics of Daunorubicin in Rats with CCl4-Induced Hepatic Injury
PURPOSE.The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug.METHODS.CCl4-EHI was induced in rats by a single intraperitoneal injection of CCl4 (1